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106-52-5 N-methyl-4-Hydroxypiperidine

106-52-5 N-methyl-4-Hydroxypiperidine

N-Methyl-4-piperidinol Basic information N-Methyl-4-piperidinol Chemical Properties Safety Information MSDS Information N-Methyl-4-piperidinol Usage And Synthesis N-Methyl-4-piperidinol Preparation Products And Raw materials Upstream information 3-chloro-4-(chlorocarbonyl) -4,...

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Product Details:

N-Methyl-4-piperidinol Basic information

Product Name:

N-Methyl-4-piperidinol

Synonyms:

1-methyl-4-piperidino; 1-Methylpiperidinol-(4); 4-Piperidinol, 1-methyl-; N-Methylpiperidol; 1-HYDROXY-4-METHYLPIPERIDINE; 1-METHYL-4-PIPERIDINOL; 1-METHYL-4-PIPERIDINOL HCL; 1-METHYL-4-PIPERIDINOLHYDROCHOLORIDE

CAS:

106-52-5

MF:

C6H13NO

MW:

115.17

EINECS:

203-406-8

Product Categories:

PHARMACEUTICAL   INTERMEDIATES;Piperidine;Building Blocks;C5 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines

Mol File:

106-52-5.mol

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N-Methyl-4-piperidinol Chemical Properties

Melting point

29-31 °C(lit.)

Boiling point

200 °C(lit.)

density

0.98 g/mL at 20 °C(lit.)

refractive index

n20/D 1.479

Fp

190 °F

storage temp.

2-8°C

form

Liquid After Melting

color

Clear colorless to brown

Water Solubility

MISCIBLE

Sensitive

Hygroscopic

BRN

103024

CAS DataBase Reference

106-52-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxy-N-methylpiperidine(106-52-5)

EPA Substance Registry System

4-Piperidinol, 1-methyl-(106-52-5)


Safety Information

Hazard Codes

Xi,C

Risk Statements

37/38-41-36/37/38-34

Safety Statements

26-37/39-45-36/37/39-27

WGK Germany

3

Hazard Note

Irritant

TSCA

Yes

HS Code

29333999


MSDS Information


N-Methyl-4-piperidinol Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ; Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis 2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ; Protein lysine methyltransferase G9a inhibitors6


N-Methyl-4-piperidinol Preparation Products And Raw materials

Raw materials

1-Methyl-4-piperidone

Preparation Products

4-(1-METHYLPIPERIDIN-4-YLOXY) -3, 5-DICHLOROBENZENAMINE


Upstream information

3-chloro-4-(chlorocarbonyl) -4, 9-dihydro-10H-thieno[3, 4-b][1, 5]benzodiazepin-10-one; 4-chlorocarbonyl-4, 9-dihydro-1-methyl-10H-thieno[3, 4-b][1, 5] benzodiazepin-10-one; benzene; Chlorodiphenylmethane; N-Methyl-4-piperidinol; 4-Fluorobenzoyl chloride; 3-Hydroxyglutaronitrile; 4-Hydroxypiperidine; Bromodiphenylmethane; 3,4-Dinitrofluorobenzene;


Downtream information

(1-methylpiperidin-4-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate; (1-methylpiperidin-4-yl) acetate; 1-Methyl-4-phenylpiperidin-4-ol; Propiverine Hydrochloride;4-Chloro-1-methylpiperidine; benzilic acid; 4-(3-methoxy-4-nitrophenoxy) -1-methylpiperidine; (1-methylpiperidin-1-ium-4-yl) 9H-fluorene-9-carboxylate,chloride; 4-NMPB; 4-bromo-1-methylpiperidine;


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