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137076-22-3 1-Boc-4-piperidinecarboxaldehyde

137076-22-3 1-Boc-4-piperidinecarboxaldehyde

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Basic information 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Chemical Properties Safety Information MSDS Information 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Usage And Synthesis 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde...

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Product Details:

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Basic information

Product Name:

1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde

Synonyms:

1-(tert-butoxycarbonyl) -4-formylpiperidine; 1-BOC-4-FORMYLPIPERIDINE 95%; 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde; 1-TERT-BUTOXYCARBONYLPIPERIDINE-4-CARBOXALDEHYDE; Piperidine-4-carboxaldehyde, N-BOC protected; TERT-BUTYL 4-FORMYLPIPERIDINE-1-CARBOXYLATE; 1-Piperidinecarboxylic acid, 4-formyl-, 1, 1-dimethylethyl ester; N-Boc-4-piperidinecarboxaldehyde

CAS:

137076-22-3

MF:

C11H19NO3

MW:

213.27

EINECS:


Product Categories:

Carbonyl Compounds; Heterocycles; pharmacetical; Piperidine; Aldehydes; Pyrans, Piperidines & Piperazines; Inhibitors; Building Blocks; C10-C12; C11; Chemical Synthesis; Heterocyclic Building Blocks; Organic Building Blocks; Piperidines

Mol File:

137076-22-3.mol

image001_副本.jpg


1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde   Chemical Properties

Melting point

34-40℃

storage temp.

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility

Soluble in methanol.

Sensitive

Air Sensitive

Density:

1.114 g/cm3

Boiling Point:

295.4ºC at 760 mmHg

Flash Point:

132.5ºC

Refractive Index:

1.519

Vapor Pressure:

0.002mmHg at 25°C

CAS DataBase Reference

137076-22-3(CAS DataBase Reference)


Safety Information

Symbol:

image003.png   GHS07 image005_副本.jpg   GHS09

Sign:

Warning

hazard declaration:

H302; H315; H319; H335; H400

hazard declaration add:


waring notice:

P261; P273; P305 + P351 + P338

Safety Statements:

S26

HS Code:

2933399090

Risk Statements:

R36/37/38

Hazard Codes:

Xi


MSDS Information


1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Usage   And Synthesis

Chemical Properties

Clear Yellow Oil

Uses

Reactant for synthesis of:• ;Pim-1 inhibitors1• ;Selective GPR119 agonists for type II diabetes2• ; M-tropic (R5) HIV-1 replication inhibitors3•; HDAC inhibitors4• ; Selective 5-HT6 antagonists5Reactant for three-component vinylogous Mannich reactions6

Uses

An intermediate for polycyclic indazole derivatives that are ERK inhibitors.


1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Dichloromethane-->Lithium aluminium hydride-->Di-tert-butyl dicarbonate-->Sodium acetate-->Manganese dioxide-->Pyridinium chlorochromate-->Isonipecotic acid-->4-Piperidinemethanol


Upstream information

L-cysteine ethylester hydrochloride; 4-(methoxy-methyl-carbamoyl) -piperidine-1-carboxylic acid tert-butyl ester; morpholine;(Carbethoxymethylene) triphenylphosphorane; tetrabromomethane; Ethyl N-Boc-piperidine-4-carboxylate; Triethyl phosphonoacetate; tert-butoxycarbonyl anhydride; Oxalyl Chloride; ethyl acetate;


Downtream information

tert-butyl 4-(2,2-dibromoethenyl) piperidine-1-carboxylate; tert-butyl 9-oxo-3-azaspiro[5.5] undec-10-ene-3-carboxylate; tert-butyl 4-(oxiran-2-yl) piperidine-1-carboxylate; ethyl 3-[[1-[ (2-methylpropan-2-yl) oxycarbonyl] piperidin-4-yl]methyl]piperidine-1-carboxylate; tert-butyl 4-[(2-sulfanylidenepiperidin-1-yl) methyl]piperidine-1-carboxylate; tert-butyl 4- (2-amino-1-hydroxybutyl) piperidine-1-carboxylate; METHYL N-BOC-4-PIPERIDINEPROPIONATE; tert-butyl 4-ethenylpiperidine-1-carboxylate; 1-Boc-4-(2-hydroxyethyl) piperidine; tert-butyl 4-[(E) -hydroxyiminomethyl]piperidine-1-carboxylate;


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