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41838-46-4 1-Methylpiperidin-4-amine

41838-46-4 1-Methylpiperidin-4-amine

1-Methylpiperidin-4-amine Basic information 1-Methylpiperidin-4-amine Chemical Properties Safety Information MSDS Information 1-Methylpiperidin-4-amine Usage And Synthesis 1-Methylpiperidin-4-amine Preparation Products And Raw materials Upstream information 3-Methoxy-4-nitrobenzoic acid;...

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Product Details:

1-Methylpiperidin-4-amine Basic information

Product Name:

1-Methylpiperidin-4-amine

Synonyms:

1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE; 4-Amino-1-methylpiperdine; 1-Methyl-4-Amino Piperidine; 4-AMINO-1-METHYLPIPERDINE, 98.5%; 1-Methylpiperidin-4-amine; 4-Amino-1-methylpiperidine; N-Methyl-4-aminopiperidine; 4-Amino-1-methylpiperidine, 97%

CAS:

41838-46-4

MF:

C6H14N2

MW:

114.19

EINECS:


Product Categories:

Pyridine; API intermediates; API intermediate

Mol File:

41838-46-4.mol

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1-Methylpiperidin-4-amine Chemical Properties

Appearance:

colorless to light-yellow liquid

Density:

0.912 g/cm3

Melting Point:

203-207ºC

Boiling Point:

55 - 60 °C at 15mmHg; 70 - 71 °C at 35mmHg

Flash Point:

39.2ºC

density

0.91

refractive index

1.4700-1.4740

CAS DataBase Reference

41838-46-4(CAS   DataBase Reference)


Safety Information

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22-34-11

Safety Statements

26-36/37/39-45-22-16-9

RIDADR

2920

Hazard Note

Irritant

HazardClass

IRRITANT

PackingGroup

Hs code

2933990090


MSDS Information


1-Methylpiperidin-4-amine Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Intermediate as

934541-31-8 TAK-901, 1253584-84-7 NMS-E973, 755038-02-9 BI 2536

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Synthesis route

image009_副本.jpg

Reference:

AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara Patent: WO2012/59932 A1, 2012 ; Location in patent: Page/Page column 137 ; WO 2012/059932 A1


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Reference:

SMITHKLINE BEECHAM CORPORATION Patent: EP1229035 A1, 2002 ; Location in patent: Page 33 ; Title/Abstract Full Text Show Details SMITHKLINE BEECHAM CORPORATION Patent: EP1227091 A2, 2002 ; Location in patent: Page 33


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Reference:

ACADIA PHARMACEUTICALS, INC. Patent: WO2007/124136 A1, 2007 ; Location in patent: Page/Page column 126-127 ; WO 2007/124136 A1


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Reference:

1. Pau, Amedeo; Boatto, Gianpiero; Cerri, Riccardo; Palagiano, Francesco;   Filippelli, Walter; Falcone, Giuseppe; Lampa, Enrico Farmaco, 1998 , vol. 53, # 3 p. 233 – 240

2. Brookes et al. Journal of the Chemical Society, 1957 , p. 3165,3171


1-Methylpiperidin-4-amine Preparation Products And Raw materials

Raw materials

Methanol-->Thionyl chloride-->Bromine-->Potassium hydroxide -->Ammonium hydroxide-->Formaldehyde-->Formic acid-->Isonipecotic acid


Upstream information

3-Methoxy-4-nitrobenzoic acid; 1-benzyl-2-chlorobenzimidazole; N-((4-methylphenyl) methyl)-N-(1-piperidin-4-yl) -4-chlorophenylacetamide; Ethanol; Methyl 1-methyl-4-oxopiperidine-3-carboxylate; 1-Methyl-4-piperidone; 4-(chlorocarbonyl) -4, 9-dihydro-1, 3-dimethyl-10H-thieno[3, 4-b][1, 5] benzodiazepin-10-one; 1-Methyl-4-piperidone Oxime Hydrochloride; N- (1-methylpiperidin-4-ylidene) hydroxylamine; 1-Methyl -4-piperidinol hydrochloride;


Downtream information

4-[(9-Cyclopentyl-7, 7-difluoro-5-methyl-6-oxo-6, 7, 8, 9-tetrahydro- 5H-pyrimido[4, 5-b][1, 4] diazepin-2-yl) amino] -3-methoxy-N-(1-methyl -4-piperidinyl) benzamide; 3-methoxy-N-(1-methylpiperidin-4-yl) -4-nitrobenzamide; 2-amino-4-methoxy-N-(1-methylpiperidin-4-yl) pyrimidine-5-carboxamide; 4-[[(7R) -8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl] amino] -3-methoxy-N-(1-methylpiperidin-4-yl) benzamide; 1-benzyl-N-(1-methylpiperidin-4-yl) benzimidazol-2-amine; 4-Amino-1-methylpiperidine hydrochloride; 4-Amino-1-methylpiperidine;


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