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632-20-2 D-Threonine

632-20-2 D-Threonine

D-Threonine Basic information D-Threonine Chemical Properties Safety Information D-Threonine Usage And Synthesis D-Threonine Preparation Products And Raw materials Upstream information 2-bromo-3-methoxy-N-phenylbutanamide; Water; benzyl alcohol; Acetic anhydride; L-threonine; Benzyl...

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Product Details:

D-Threonine Basic information

Product Name:

D-Threonine

Synonyms:

(r)-threonine;d-threonin;D-α-Amino-β-hydroxybutyric acid ;D-THREONINE, 98% (99% EE/GLC);D-THREONINE, FREE OF ALLOTHREONINE;D-Threonine,>99%;D-THREONINE    extrapure;(2R,3S)-2-Amino-3-hydroxybutyric    acid, D-α-Amino-β-hydroxybutyric acid

CAS:

632-20-2

MF:

C4H9NO3

MW:

119.12

EINECS:

211-171-8

Product Categories:

Amino ACIDS SERIES;Miscellaneous;PROTECTED AMINO ACID & PEPTIDES;Threonine [Thr, T];Amino Acids and Derivatives;alpha-Amino   Acids;Amino Acids;Biochemistry;Amino Acids;amino acid;amino

Mol File:

632-20-2.mol

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D-Threonine Chemical Properties

alpha 

28 º (c=6, water)

refractive index 

28 ° (C=3, H2O)

solubility 

H2O: soluble

form 

Crystals or Crystalline Powder

color 

White

Water Solubility 

soluble

Appearance:

White to off white crystal

Density:

1.307 g/cm3

Melting    Point:

274ºC

Boiling    Point:

345.8ºC at 760 mmHg

Flash    Point:

162.9ºC

Storage   Condition:

Store at RT.

Merck 

9380

BRN 

1721643

InChIKey

AYFVYJQAPQTCCC-STHAYSLISA-N

CAS DataBase Reference

632-20-2(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-37/39-26

WGK Germany 

3

RTECS 

XO8580000

HS Code 

29225000


D-Threonine Usage And Synthesis

Description

D-threonine is the D-form of    threonine, which is a kind of amino acids. It can be used for the preparation    of enantiomerically pure 1, 3-butanediol. It is also used as the intermediate    during the preparation of chiral compounds such as antibiotics. D-threonine    is an effective chiral pool reagent which contains an extra stereo-center.    For example, people has recently used it as the starting material for total    synthesis of protected legionaminic acid.

Chemical Properties

white crystalline powder or    crystals

Uses

A steroisomer of the proteinogenic    amino acid L-threonine.

Intermediate as

1182367-47-0 RAD140, 627530-84-1    BMS-564929, 76610-84-9 Cefbuperazone

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Synthesis route

 

Definition

ChEBI: An optically active form of    threonine having D-configuration.

References

https://www.alfa.com/zh-cn/catalog/B21177/  Ikemi, Masahisa, et al. "D-Threonine Aldolase and Its Application to D -The tail-Hydroxy-

gathering-Amino Acid Synthesis."(1992).

Paek SM, et al. "Recent Advances in Substrate-Controlled Asymmetric   Induction Derived from Chiral Pool pseudo -Amino Acids for Natural Product Synthesis." Molecules 21.7(2016):951.


D-Threonine Preparation Products And Raw materials

Raw materials

Chloroacetyl    chloride-->DL-Threonine-->AMINOACYLASE

Preparation Products

(2S,3S)-2-Amino-3-methylpentanoic    acid-->Cefbuperazone


Upstream information

2-bromo-3-methoxy-N-phenylbutanamide; Water; benzyl alcohol; Acetic anhydride; L-threonine; Benzyl chloroformate; N-methyl-threonine; ethyl (Z)-2-(hydroxyimino)-3-oxobutyrate; ethyl 2-acetamido-3-oxobutanoate; propan-2-ol;


Downtream information

methyl (2R,3S)-2,3-dihydroxybutanoate; N-methyl-threonine; L-threonine; (2R,3S)-Methyl 2-amino-3-hydroxybutanoate hydrochloride; D-glutamic acid;valine; N-methyl-L-valine; benzyl (2R,3S)-2-amino-3-hydroxybutanoate; (2R,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxybutanoic acid; N-Cbz-D-threonine

 

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