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68832-13-3 (R)-pyrrolidin-2-ylmethanol

68832-13-3 (R)-pyrrolidin-2-ylmethanol

D(-)Prolinol Basic information D(-)Prolinol Chemical Properties Safety Information D(-)Prolinol Usage And Synthesis D(-)Prolinol Preparation Products And Raw materials Upstream information Benzyl chloroformate; D-prolinol; dimethyl 2-aminopentanedioate,hydrochloride; D-glutamic acid; benzyl...

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Product Details:

D(-)Prolinol Basic information

Product Name:

D(-)Prolinol

Synonyms:

(2R)-PYRROLIDIN-2-YLMETHANOL;(+)-D-PROLINOL;D(-)PROLINOL;D-PROLINOL;H-D-PROLINOL;H-D-PRO-OL;(R)-(-)-2-(Hydroxymethyl)pyrrolidine    (R)-(-)-2-Pyrrolidinemethanol;(R)-(-)-PyrrolidinemethanolD-Prolinol

CAS:

68832-13-3

MF:

C5H11NO

MW:

101.15

EINECS:

1592732-453-0

Product Categories:

Pharmaceutical Intermediates;Proline [Pro, P];Amino    Alcohols;Chiral    Building Blocks;Glycidyl    Compounds, etc. (Chiral);Synthetic    Organic Chemistry;Amino    alcohols

Mol File:

68832-13-3.mol

image001.gif


D(-)Prolinol Chemical Properties

alpha 

-31 º (c=1, toluene)

Boiling point 

74-76 °C2 mm Hg(lit.)

density 

1.036 g/mL at    20 °C(lit.)

Fp 

187 °F

form 

Solution

color 

Clear to slightly hazy colorless    to amber

Sensitive 

Air Sensitive

BRN 

1523669

Appearance:

clear to yellow liquid

Flash    Point:

86.1ºC

Refractive   Index:

1.483-1.486

Storage   Condition:

2-8ºC

InChIKey

HVVNJUAVDAZWCB-RXMQYKEDSA-N

CAS DataBase Reference

68832-13-3(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-26/36

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

3-10-23

Hazard Note 

Irritant/Air Sensitive

HazardClass 

IRRITANT

Hs code

2933990090


D(-)Prolinol Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Definition

ChEBI: The D-enantiomer of    prolinol. Metabolite observed in cancer metabolism.

Intermediate as

1165910-22-4 LGD4033

image003_副本.jpg

Synthesis route

image005_副本.jpg

Reference:

Journal of the Chemical Society, Dalton    Transactions: Inorganic Chemistry (1972-1999), , p. 1149 - 1156

image007_副本.jpg

Reference:

Journal of the Chemical Society, Dalton    Transactions: Inorganic Chemistry (1972-1999), , p. 1149 - 1156

image009_副本.jpg

Reference:

US5130432 A1


D(-)Prolinol Preparation Products And Raw materials


Upstream information

Benzyl chloroformate; D-prolinol; dimethyl 2-aminopentanedioate,hydrochloride; D-glutamic acid; benzyl bromide; iodomethane; 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; Methyl L-Pyroglutamate; tert-butoxycarbonyl anhydride; N-(Benzyloxycarbonyloxy)succinimide;


Downtream information

(3aR)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-c]oxathiazole 1,1-dioxide; benzyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate; N-(TERT-BUTOXYCARBONYL)-D-PROLINAL; D-prolinol; [(2R)-1-benzylpyrrolidin-2-yl]methanol; (1-methylpyrrolidin-2-yl)methanol; tert-butyl (2R)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate;Tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate; tert-butyl (2R)-2-(aminomethyl)pyrrolidine-1-carboxylate; benzyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

 

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