Lianyungang Klinechem Co.,Ltd
call us on: +86-518-88103268
English中文

16153-81-4 4-(4-Methylpiperazino)aniline

16153-81-4 4-(4-Methylpiperazino)aniline

4-(4-Methylpiperazino)aniline Basic information 4-(4-Methylpiperazino)aniline Chemical Properties Safety Information 4-(4-Methylpiperazino)aniline Usage And Synthesis 4-(4-Methylpiperazino)aniline Preparation Products And Raw materials Upstream information 4-Fluoronitrobenzene;...

Chat Now
Product Details:

4-(4-Methylpiperazino)aniline Basic information

Product Name:

4-(4-Methylpiperazino)aniline

Synonyms:

OTAVA-BB BB7110920492;AKOS BB-8657;AKOS B021941;4-(4-METHYLPIPERAZINO)ANILINE;4-(4-METHYLPIPERAZINE)ANILINE;4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINE;4-(4-METHYLPIPERAZIN-1-YL)ANILINE;1-(4-AMINOPHENYL)-4-METHYLPIPERAZINE

CAS:

16153-81-4

MF:

C11H17N3

MW:

191.27

EINECS:

 

Product Categories:

PIPERIDINE;Amines and Anilines;Heterocycles;Amines;Phenyls & Phenyl-Het;Piperaizine;API intermediates;Piperazidine intermediates;Piperazines;Phenyls & Phenyl-Het

Mol File:

16153-81-4.mol

image001.gif


4-(4-Methylpiperazino)aniline Chemical Properties

Appearance:

Kind of white to yellow powder

Density:

1.092 g/cm3

Melting    Point:

89-91ºC

Boiling    Point:

351.5ºC at 760 mmHg

Boiling point 

180°C/5mmHg(lit.)

Flash    Point:

164ºC

Vapor   Pressure:

4.09E-05mmHg at 25°C

Sensitive 

Air Sensitive

CAS DataBase Reference

16153-81-4(CAS    DataBase Reference)


Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3259

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

Hs code

2933599090


4-(4-Methylpiperazino)aniline Usage And Synthesis

Description

4-(4-Methylpiperazino)aniline is a reagent in the    preparation of benzyloxypyridinone derivative which has c-Met kinase    inhibitor properties.

Chemical Properties

Purple solid

Intermediate as

955365-80-7 MK-1775, 936091-14-4    TG101209, 802539-81-7 Milciclib (PHA-848125), 1214265-56-1 WZ-3146,    80259-18-3 JP1302
     

image003_副本.jpg

image005_副本.jpg

image007_副本.jpg

image009_副本.jpg

image011_副本.jpg

Synthesis route

image013_副本.jpg

Reference:

1. European Journal of Medicinal Chemistry, vol.46, # 7 p. 2917-2929
2. WO2011/120025 A1
3. Journal of Medicinal Chemistry, vol. 48, # 26 p. 8261-8269
4. Bioorganic and Medicinal Chemistry Letters, vol.14, #5p. 1221-1227
       
       

image015_副本.jpg

Reference:

1. WO2013/43232 A2, ; WO 2013/043232 A2
2. Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269

image017_副本.jpg

Reference:

Journal of Organic Chemistry, , vol. 14, p.771,772

image019_副本.jpg

Reference:

European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929


4-(4-Methylpiperazino)aniline Preparation Products And Raw materials

Raw materials

Ethyl    acetate-->Methanol-->N,N-Dimethylformamide-->Potassium    carbonate-->Chloroform-->Dimethyl    sulfoxide-->4-Chloronitrobenzene-->1-Methylpiperazine-->Palladium    hydroxide


Upstream information

4-Fluoronitrobenzene; bis(trichloromethyl) carbonate; thiophosgene; 1-Methyl-4-(4-nitrophenyl)piperazine; 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methylsulfanyl-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one; 3-(6-(4-isocyanatophenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane; 4-chloro-6-phenylquinoline; 1-Bromo-4-nitrobenzene; 1-Methylpiperazine; 4-Chloronitrobenzene;


Downtream information

N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide; 1-(4-Isothiocyanatophenyl)-4-methylpiperazine; 5-methyl-2-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidine-2,4-diamine; N-[4-(4-methylpiperazin-1-yl)phenyl]-6-phenylquinolin-4-amine; 1-(4-isocyanatophenyl)-4-methylpiperazine; 4-chloroquinoline-3-carbonitrile; 4-(4-Methylpiperazino)aniline; 1-[4-(4-Methyl-1-piperazinyl)phenyl]-3-{4-[4-(8-oxa-3-azabicyclo[ 3.2.1]oct-3-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimi din-6-yl]phenyl}ure; 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one; N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine

 

Related Product Information

N-[4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE 5-[4-(4-NITROPHENYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE METHYL N-CYANO-4-(4-NITROPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBIMIDOTHIOATE 2,2,2-TRICHLORO-N-[4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE 2,2-DICHLORO-N-[4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE 2-[4-(4-NITROPHENYL)PIPERAZINO]QUINOXALINE BUTTPARK 83\09-70 3-CHLORO-N-[4-(4-METHYLPIPERAZINO)PHENYL]BENZENECARBOXAMIDE ETHYL 5-(3,4-DICHLOROPHENYL)-2-[4-(4-NITROPHENYL)PIPERAZINO]-1H-PYRROLE-3-CARBOXYLATE 4-(4-BENZYLPIPERAZINO)ANILINE 4-CHLORO-N-[4-(4-METHYLPIPERAZINO)PHENYL]BENZENECARBOXAMIDE 4-(4-Methylpiperazino)aniline 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE N,N-Dimethyl-1,4-phenylenediamine Benzhydrylpiperazine 4-Aminobenzotrifluoride Aniline 3,3',5,5'-Tetramethylbenzidine dihydrochloride


Hot Tags: 16153-81-4 4-(4-methylpiperazino)aniline, suppliers, manufacturers, factory, bulk, cheap, discount
Feedback
Contact Us
Address: Jingqi Road, Weiwu Road, Coastal Industrial Park, Guanyun County, Lianyungang City, Jiangsu Province
Tel:+86-518-88103268
Fax:+86-518-88103267
E-mail:sales@klinechem.com

Copyright © Lianyungang Klinechem Co.,Ltd