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23785-21-9 Ethyl 1H-imidazole-5-carboxylate

23785-21-9 Ethyl 1H-imidazole-5-carboxylate

Ethyl imidazole-4-carboxylate Basic information Ethyl imidazole-4-carboxylate Chemical Properties Safety Information Ethyl imidazole-4-carboxylate Usage And Synthesis Ethyl imidazole-4-carboxylate Preparation Products And Raw materials Upstream information (S)-1-phenylethanol; ethyl...

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Product Details:

Ethyl imidazole-4-carboxylate Basic information

Product Name:

Ethyl    imidazole-4-carboxylate

Synonyms:

ETHYL 4-IMIDAZOLECARBOXYLATE;ETHYL    IMIDAZOLE-4(5)-CARBOXYLATE;ETHYL    IMIDAZOLE-4-CARBOXYLATE;ETHYL    1H-IMIDAZOLE-4-CARBOXYLATE;ETHYL    1H-IMIDAZOLE-5-CARBOXYLATE;RARECHEM AL BI    0762;IMIDAZOLE-4-CARBOXYLICACIDETHYLESTER;Ethyl 1H-imidazole-4-carboxylate 98%

CAS:

23785-21-9

MF:

C6H8N2O2

MW:

140.14

EINECS:

1308068-626-2

Product Categories:

blocks;Carboxes;Imidazoles;pharmacetical;Heterocycle

Mol File:

23785-21-9.mol

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Ethyl imidazole-4-carboxylate Chemical Properties

form 

Solid

Appearance:

White crystalline powder

Density:

1.214g/cm3

Melting    Point:

160-162ºC

Boiling    Point:

319.5ºC at 760mmHg

Flash    Point:

147ºC

Refractive   Index:

1.521

Vapor   Pressure:

0.00723mmHg at 25°C

Water Solubility 

Soluble in dimethyl sulfoxide and    methanol. Slightly soluble in water.

λmax

234nm(CH3CN)(lit.)


Safety Information


Hazard Codes 

Xi

Safety Statements 

24/25

Hazard Note 

Irritant

Hs code

2933290090



Ethyl imidazole-4-carboxylate Usage And Synthesis

Chemical Properties

White to light yellow crystal,    powder or crystalline powder

Description

4-Carbethoxyimidazole, is a    ring-substituted-1H-imidazole-4-carboxylic acid derivative, that is shown to    act as a new class of anti-tuberculosis agents.

Intermediate as

33125-97-2 Etomidate, 86347-14-0    Medetomidine,113775-47-6 Dexmedetomidine

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Synthesis route

image009_副本.jpg

Reference:

Myles, Lauren; Gore, Rohitkumar G.;    Gathergood, Nicholas; Connon, Stephen J. Green Chemistry, 2013 , vol. 15, #    10 p. 2740 - 2746

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Reference:

Journal of the Chemical Society, , p.    1074,1076

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Reference:

Journal of the American Chemical Society, ,    vol. 71, p. 644,645


Ethyl imidazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Hydrochloric    acid-->Nitric    acid-->Sodium    nitrite-->Acetic    anhydride-->Acetone-->Sodium    methanolate-->Formic    acid-->Ethyl    formate-->Sodium    formate-->Glycine    ethyl ester hydrochloride-->Potassium thiocyanate-->N-Acetylglycine


Upstream information

(S)-1-phenylethanol; ethyl 1H-imidazole-5-carboxylate; Ethyl 2-mercapto-1H-imidazole-4-carboxylate; ethyl 5-amino-2-sulfanylidene-3H-1,3-thiazole-4-carboxylate; Ethanol; 1H-Imidazole-4-carboxylic acid; Triphenylmethyl bromide; carbon dioxide; Triphenylmethyl Chloride; Formaldehyde;


Downtream information

Ethyl 1-Methylimidazole-5-carboxylate; ethyl 1H-imidazole-5-carboxylate; etomidate; Ethyl 1-trityl-1H-imidazole-4-carboxylate; ethyl 3-aminoimidazole-4-carboxylate; 1H-imidazole-5-carboxamide; Ethyl 1-Methylimidazole-4-carboxylate; 1H-imidazole-5-carbohydrazide; imidazole-4-methanol

 

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