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24241-18-7 2-Amino-3,5-dibromopyrazine

24241-18-7 2-Amino-3,5-dibromopyrazine

2-Amino-3,5-dibromopyrazine Basic information 2-Amino-3,5-dibromopyrazine Chemical Properties Safety Information 2-Amino-3,5-dibromopyrazine Usage And Synthesis 2-Amino-3,5-dibromopyrazine Preparation Products And Raw materials Upstream information piperidine; Ethyl bromopyruvate; Sodium...

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Product Details:

2-Amino-3,5-dibromopyrazine Basic information

Product Name:

2-Amino-3,5-dibromopyrazine

Synonyms:

2-AMINO-3,5-DIBROMOPYRAZINE;3,5-DIBROMOPYRAZIN-2-YLAMINE;3,5-DIBROMOPYRAZINE-2-YLAMINE;3,5-DIBROMOPYRAZIN-2-AMINE;2-AMINO-3,5-DIBROMOPYRAZIN;3,5-dibromo-2-Pyrazinamine;3,5-dibromo-2-aminopyrazine;2-Amino-3,5-dibromopyrazine ,98%

CAS:

24241-18-7

MF:

C4H3Br2N3

MW:

252.89

EINECS:

 

Product Categories:

pharmacetical;Pyrazines;Chloropyrazines, etc.;Pyrazine;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrazinesHeterocyclic Building Blocks;amine| alkyl bromide

Mol File:

24241-18-7.mol

image001.gif


2-Amino-3,5-dibromopyrazine Chemical Properties

form 

Powder

color 

Yellow to brown

Appearance:

white to light yellow crystal    powde

Density:

2.287

Melting    Point:

114-117ºC

Boiling    Point:

294.6ºC at 760 mmHg

Flash    Point:

131.9ºC

Refractive   Index:

1.685

Storage   Condition:

Refrigerator

Vapor   Pressure:

0.00161mmHg at 25°C

CAS DataBase Reference

24241-18-7(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41

Safety Statements 

26-36/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

Hs code

2933990090


2-Amino-3,5-dibromopyrazine Usage And Synthesis

Chemical Properties

white to light yellow crystal    powde

Uses

2-Amino-3,5-dibromopyrazine is    used in the preparation of conjugated polymers for neurotoxin detection.    2-Amino-3,5-dibromopyrazine is an intermediate in the preparation of rho    kinase (ROCK) inhibitors.

Intermediate as

956905-27-4 PF-04217903

image003_副本.jpg

Synthesis route

image005_副本.jpg

Reference:

  1. Paudler, William W.; Jovanovic, Misa V. Journal of Organic Chemistry, 1983 , vol. 48,# 7 p. 1064 - 1069

  2. Chemical Communications, , vol. 47, # 16 p. 4688 - 4690

  3. Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 673 - 674

image007_副本.jpg

Reference:

Heterocycles, , vol. 86, # 2 p. 1323 - 1339


2-Amino-3,5-dibromopyrazine Preparation Products And Raw materials


Upstream information

piperidine; Ethyl bromopyruvate; Sodium thiomethoxide; 2-bromo-1,1-diethoxyethane; Ethyl acetoacetate; Benzylmagnesium chloride; 1-(4-methoxyphenyl)methanamine; phenol; Sodium methoxide; 4-Fluorobenzeneboronic acid;


Downtream information

3,5-dibromopyrazin-2-amine; 3,5-Dimethoxy-2-pyrazinamine; 5-bromo-3-N-[(4-methoxyphenyl)methyl]pyrazine-2,3-diamine; 5-bromo-3-(2-trimethylsilylethynyl)pyrazin-2-amine; Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate; 6,8-Dibromoimidazo[1,2-a]pyrazine; 3,5-dibromo-N,N-dimethylpyrazin-2-amine; 2-Amino-5-bromo-3-morpholin-4-ylpyrazine; 2-Amino-5-bromo-3-piperidin-1-ylpyrazine; 5-bromo-3-hydrazinylpyrazin-2-amine

 

Related Product Information

Pyrazine Glycine 6-Aminocaproic acid Aminopyrazine 3-Aminophenol Glipizide 3,5-DIBROMO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZIN-2-AMINE 3,5-DIBROMO-6-(4-FLUOROPHENYL)-N-METHYLPYRAZIN-2-AMINE 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE ALTRENOGEST 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE 2-Amino-3,5-dibromopyrazine AMINO ACIDS Tris Base Pyrazinamide


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