Lianyungang Klinechem Co.,Ltd
call us on: +86-518-88103268
English中文

3680-69-1 4-Chloropyrrolo[2,3-d]pyrimidine

3680-69-1 4-Chloropyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Basic information 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties Safety Information 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis

Chat Now
Product Details:

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Basic information

Product Name:

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Synonyms:

4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE;4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;3-d)pyrimidine,4-chloro-7h-pyrrolo(;6-CHLORO-7-DEAZAPURINE   4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE   4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN;4-Chloro-1H-pyrrolo[2,3-d]pyrimidine4-Chloropyrrolo[2,3-d]pyrimidine;6-Chloro-7-deazapurin

CAS:

3680-69-1

MF:

C6H4ClN3

MW:

153.57

EINECS:

2017-001-1

Product Categories:

Heterocycles;Heterocycles series;Halides;Pyrimidine;Heterocyclic Compounds;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides &   Related Reagents;CHIRAL   CHEMICALS;Naphthyridine,Quinoline;Bases & Related Reagents;Intermediates;Nucleotides;Fused Ring Systems;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series;Baricitinib;Ruxolitinib;Tofacitinib

Mol File:

3680-69-1.mol

image001.gif



4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties

form

Crystalline Powder

color

White to tan

Appearance:

light brown to brown crystalline powder

Density:

1.531 g/cm3

Melting Point:

186-189ºC

Boiling Point:

325.9ºC at 760 mmHg

Flash Point:

180.7ºC

Refractive Index:

1.702

solubility

Soluble in DMSO, ethyl acetate and methanol.

storage temp.

Room temperature.

InChIKey

BPTCCCTWWAUJRK-UHFFFAOYSA-N

CAS DataBase Reference

3680-69-1(CAS DataBase Reference)


Safety Information

Hazard Codes

Xi,T,Xn

Risk Statements

36/37/38-25-20/21/22

Safety Statements

26-37-45-36

RIDADR

UN 2811 6.1/PG 3

RTECS

UY9360000

HazardClass

IRRITANT

PackingGroup

Hs code

2942000000


4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis

Chemical Properties

Lightbrown to brown crystalline powder

Uses

used in the manufacture of Tofacitinib citrate.

Intermediate as

1143532-39-1 AZD5363, 941678-49-5 Ruxolitinib (INCB018424), 885499-61-6 CCT128930


image003_副本.jpg

image005_副本.jpg

image007_副本.jpg

Synthesis route

image009_副本.jpg

Reference:

Heinrich, Timo; Staehle, Wolfgang; Greiner, Hartmut; Blaukat, Andree Patent: US2010/160356 A1, 2010; Location in patent: Page/Page column 33;


image011_副本.jpg

Reference:

Kim, Jiae; Wang, Ligong; Li, Yongfeng; Becnel, Kimberlynne D.; Frey, Kathleen M.; Garforth, Scott J.; Prasad, Vinayaka R.; Schinazi, Raymond F.; Liotta, Dennis C.; Anderson, Karen S. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4064 - 4067


image013_副本.jpg

Reference:

1. Tsytovich, A. V.; Shamshin, D. V.; Burkovskii, V. B.; Shvets, V. I. Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 11 p. 756 - 761 Bioorganicheskaya   Khimiya, 1995 , vol. 21, # 11 p. 874 - 880

2. Diederichsen, Ulf; Schmitt, Harald W. European Journal of Organic Chemistry, 1998 , # 5 p. 827 - 835


image015_副本.jpg

Reference:

Tsytovich, A. V.; Shamshin, D. V.; Burkovskii, V. B.; Shvets, V. I. Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 11 p. 756 - 761 Bioorganicheskaya Khimiya, 1995 , vol. 21, # 11 p. 874 -   880


4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Sodium-->Phosphorus   oxychloride-->Potassium   carbonate-->Ammonium   chloride -->Ethyl   cyanoacetate-->Thiocarbamide-->Sodium   iodide -->Bromoacetaldehyde   diethyl acetal-->RANEY   NICKEL-->Pyrrolo[2,3-d]pyrimidin-4-ol


Upstream information

2-Bromopropane; piperazine; 1,2,3,4-Tetrahydro-2-naphthol; 4-Chloropyrrolo[2,3-d]pyrimidine; 2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride; methanol; potassium cyanide; Trimethylaluminium; (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile; 2-Iodopropane;


Downtream information

4-Amino-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloropyrrolo[2,3-d]pyrimidine; 6-Benzylamino-7-deazapurine; 6-Chloro-7-deaza-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranoysyl)purine; [(2S,5R)-5-(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)oxolan-2-yl]methanol; 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine; 4-chloro-7-propan-2-ylpyrrolo[2,3-d]pyrimidine; 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone; trimethyl-[2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl]silane

 


Hot Tags: 3680-69-1 4-chloropyrrolo[2,3-d]pyrimidine, suppliers, manufacturers, factory, bulk, cheap, discount
Feedback
Contact Us
Address: Jingqi Road, Weiwu Road, Coastal Industrial Park, Guanyun County, Lianyungang City, Jiangsu Province
Tel:+86-518-88103268
Fax:+86-518-88103267
E-mail:sales@klinechem.com

Copyright © Lianyungang Klinechem Co.,Ltd