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695-95-4 Methyl 3-oxocyclobutanecarboxylate

695-95-4 Methyl 3-oxocyclobutanecarboxylate

METHYL 3-OXOCYCLOBUTANECARBOXYLATE Basic information METHYL 3-OXOCYCLOBUTANECARBOXYLATE Chemical Properties METHYL 3-OXOCYCLOBUTANECARBOXYLATE Usage And Synthesis Upstream information methyl 3-methylidenecyclobutane-1-carboxylate; 3-methylidenecyclobutane-1-carboxylic acid; methanol;...

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Product Details:

METHYL 3-OXOCYCLOBUTANECARBOXYLATE Basic information

Product Name:

METHYL    3-OXOCYCLOBUTANECARBOXYLATE

Synonyms:

METHYL 3-OXOCYCLOBUTANECARBOXYLATE;3-methoxycarbonylcyclobutanone;Methyl 3-oxo-cyclobutanec...;Cyclobutanecarboxylic acid, 3-oxo-, Methyl ester;Methyl oxetane-3-carboxylate;methyl 3-oxocyclobutane-1-carboxylate;3-Oxo-cyclobutanecarboxylic acid methyl ester

CAS:

695-95-4

MF:

C6H8O3

MW:

128.12592

EINECS:

 

Product Categories:

 

Mol File:

695-95-4.mol

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METHYL 3-OXOCYCLOBUTANECARBOXYLATE Chemical Properties

Water Solubility

Slightly soluble in water.

Density:

1.219g/cm3

Boiling    Point:

188ºC at 760 mmHg

Flash    Point:

72.5ºC

Refractive   Index:

1.473

Hs   code

2918300090


METHYL 3-OXOCYCLOBUTANECARBOXYLATE Usage And Synthesis

Description

3-Oxocyclobutanecarboxylic Acid Methyl Ester,can be used as an intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.

Intermediate as

1380288-87-8 EPZ5676

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Synthesis route

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Reference:

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; GRAHAM , Keith; SCHMITT-WILLICH , Heribert; FRANCK , Dominic Patent:WO2011/6621 A1, 2011 ; Location in patent: Page/Page column 36 
WO2012/58187 A1, ; Page/Page column 53 ; WO    2012/058187 A1

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Reference:

Synthesis, , vol. 44, # 6 p. 903 - 908

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Reference:

Chemische Berichte, , vol. 100, p. 2107 -    2116

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Reference:

Chemische Berichte, , vol. 100, p. 2107 -    2116

image013_副本.jpg

Reference:

Chemische Berichte, , vol. 100, p. 2107 -    2116


Upstream information

methyl 3-methylidenecyclobutane-1-carboxylate; 3-methylidenecyclobutane-1-carboxylic acid; methanol; diazomethyl(trimethyl)silane; methyl 3-(benzylimino)cyclobutanecarboxylate; 3-Methylenecyclobutane-1-Carbonitrile; 3-oxocyclobutane-1-carboxylic acid; Methyl 3-oxocyclobutanecarboxylate;Trimethoxymethane;


Downtream information

3-(Hydroxymethyl)cyclobutanone; Methyl 3,3-dimethoxycyclobutanecarboxylate; 5,8-dioxaspiro[3.4]octan-2-ylmethanol; methyl 3-hydroxy-3-phenylcyclobutane-1-carboxylate; Methyl 3-oxocyclobutanecarboxylate

 

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