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705263-10-1 6-bromopyrazolo[1,5-a]pyrimidine

705263-10-1 6-bromopyrazolo[1,5-a]pyrimidine

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Basic information 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties Safety Information 6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials Upstream information 6-Bromopyrazolo[1,5-a]pyrimidine; 2-bromopropanedial; 3-Aminopyrazole;...

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Product Details:

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Basic information

Product Name:

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE

Synonyms:

6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE;6-Bromopyrazolo[1,5-a]pyr...;6-broMopyrazolo[1;Pyrazolo[1,5-a]pyriMidine,    6-broMo-

CAS:

705263-10-1

MF:

C6H4BrN3

MW:

198.02

EINECS:

 

Product Categories:

Heterocycle-Pyrimidine    series

Mol File:

705263-10-1.mol

image001.gif


6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties

Melting point 

122-124℃

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

Density:

1.891g/cm3

Refractive   Index:

1.751


Safety Information

Hs code

2933990090


6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Usage And Synthesis

Description

6-Bromopyrazolo[1,5-a]pyrimidine is a reactant in the    synthesis of LDN-212854, a selective and potent inhibitor of the BMP type I    receptor kinases.


Intermediate as

1062368-24-4 LDN-193189,    1432597-26-6 LDN-212854, 1062368-62-0 LDN-193189 HCl

image003_副本.jpg


       

image005_副本.jpg

image007_副本.jpg

Synthesis route

image009_副本.jpg

Reference:

  1. THE GENERAL HOSPITAL CORPORATION; THE BRIGHAM AND WOMEN'S HOSPITAL, INC. Patent:WO2009/114180 A1, 2009 ; Location in patent: Page/Page column 71

  2. Cuny, Gregory D.; Yu, Paul B.; Laha, Joydev K.; Xing,   Xuechao; Liu, Ji-Feng; Lai, Carol S.; Deng, Donna Y.; Sachidanandan, Chetana;    Bloch, Kenneth D.; Peterson, Randall T. Bioorganic and Medicinal Chemistry  Letters, 2008 , vol. 18, # 15 p. 4388 - 4392

  3. WO2006/128692 A2, ; Page/Page column 86

  4. WO2009/14620 A1, ; Page/Page column 36; 24 ; WO 2009/014620 A1


6-BROMO-PYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials


Upstream information

6-Bromopyrazolo[1,5-a]pyrimidine; 2-bromopropanedial; 3-Aminopyrazole; 1H-Pyrazol-3-amine; (2Z)-2-bromo-3-(dimethylamino)prop-2-enal;


Downtream information

5-Bromo-1H-Pyrazolo[3,4-b]Pyridine; 6-Bromopyrazolo[1,5-a]pyrimidine; 6-Bromo-3-iodopyrazolo[1,5-a]pyrimidine

  

Related Product Information

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