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875781-17-2 5-Bromo-1H-pyrazolo[3,4-b]pyridine

875781-17-2 5-Bromo-1H-pyrazolo[3,4-b]pyridine

5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Basic information 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Chemical Properties Safety Information 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Usage And Synthesis 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Preparation Products And Raw materials Upstream information 2-bromopropanedial;...

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Product Details:

5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Basic information

Product Name:

5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE

Synonyms:

5-bromo-1H-pyrazoio[3,4-b]pyridine;5-Bromopyrazolo[3,4-b]pyridine;5-Bromo-1H-pyrazolo[3,4-b]pyridine;4-b]pyridine;5-broMo-1H-pyrazolo[3;1H-Pyrazolo[3,4-b]pyridine, 5-broMo-;7-Aza-5-bromo-1H-indole;5-Bromopyrazolo[3,4-b]pyridine

CAS:

875781-17-2

MF:

C6H4BrN3

MW:

198.023

EINECS:

-0

Product Categories:

CHIRAL CHEMICALS;Building Blocks;Pyrazolo[x,x-y]pyridine

Mol File:

875781-17-2.mol

image001.gif


5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Chemical Properties

Melting point 

198.0 to 202.0 °C

form 

Solid

Density:

1.894 g/cm3

Boiling    Point:

329ºC at 760 mmHg

Flash    Point:

152.8ºC

Refractive   Index:

1.68

InChIKey

BASYLPMLKGQZOG-UHFFFAOYSA-N


Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

HazardClass 

IRRITANT

Hs code

2933990090


5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Usage And Synthesis

Intermediate as

1421783-64-3 GZD824 Dimesylate
     

image003_副本.jpg

Synthesis route

image005_副本.jpg

Reference:

  1. ARRAY BIOPHARMA INC.; GENENTECH, INC.; AHRENDT, Kateri A.; BUCKMELTER, Alexandre J.; DE MEESE, Jason; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen R.; LUNGHOFER, Paul; MORENO, David; NEWHOUSE, Brad; REN, Li; SEO, Jeongbeob;TIAN, Hongqi; WENGLOWSKY, Steven Mark; FENG, Bainian; GUNZNER, Janet;    MALESKY, Kim; MATHIEU, Simon; RUDOLPH, Joachim; WEN, Zhaoyang; YOUNG, Wendy  B. Patent: WO2009/111279 A1, 2009 ; Location in patent: Page/Page column  79-80 ;WO 2009/111279 A1

  2. ELI LILLY AND COMPANY Patent: WO2006/52568 A2, 2006 ;   Location in patent: Page/Page column 23-24 ; WO 2006/052568 A2

  3. WO2006/128692 A2, ; Page/Page column 86

image007_副本.jpg

Reference:

US2008/293706 A1, ; Page/Page column 85 ; US 20080293706 A1

image009_副本.jpg

Reference:

US2008/261921 A1, ; Page/Page column 73-74 ; US 20080261921 A1


5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Preparation Products And Raw materials


Upstream information

2-bromopropanedial; 5-Bromo-1H-Pyrazolo[3,4-b]Pyridine; 5-bromo-3-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)-2(1H)-pyridinone hydrazone; 3-(Morpholine-4-carbonyl)phenylboronic acid; N-iodosuccinimide; 5-Bromo-2-fluoropyridine-3-carboxaldehyde; 5-bromo-3-(1,3-dioxolan-2-yl)-2-hydrazinylpyridine hydrochloride; 3-Aminopyrazole; 1H-Pyrazol-3-amine;


Downtream information

triphenylphosphane oxide; 6-Bromopyrazolo[1,5-a]pyrimidine; morpholin-4-yl-[3-(1H-pyrazolo[3,4-b]pyridin-5-yl)-phenyl]-methanone; 5-Bromo-1H-Pyrazolo[3,4-b]Pyridine; 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid; 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine; 5-ethynyl-1H-pyrazolo[3,4-b]pyridine

 

Related Product Information

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