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25487-66-5 3-Carboxyphenylboronic Acid

25487-66-5 3-Carboxyphenylboronic Acid

3-Carboxyphenylboronic acid Basic information 3-Carboxyphenylboronic acid Chemical Properties Safety Information 3-Carboxyphenylboronic acid Usage And Synthesis 3-Carboxyphenylboronic acid Preparation Products And Raw materials Upstream information Methyl 3-bromobenzoate; Ethanol;...

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Product Details:

3-Carboxyphenylboronic acid Basic information

Product Name:

3-Carboxyphenylboronic    acid

Synonyms:

3-(dihydroxyboranyl)benzoic acid;3 - carboxyl benzene    boric acid;RARECHEM AH PB 0148;3-borono-benzoicaci;m-borono-benzoicaci;m-carboxy-benzeneboronicaci;m-carboxybenzeneboronicacid;M-CARBOXYPHENYLBORONIC ACID

CAS:

25487-66-5

MF:

C7H7BO4

MW:

165.94

EINECS:

-0

Product Categories:

Boronate Ester;Potassium Trifluoroborate;Boric Acid| Boric Acid Ester| Potassium Trifluoroborate| carboxylic acid;Eltrombopag/Lumacaftor;Thiophenes;blocks;BoronicAcids;Carboxes;Boronic Acid series;Acids and Derivatives;Boron, Nitrile, Thio,& TM-Cpds;Substituted Boronic Acids;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic    acids;Boronic Acid;Aryl;Organoborons;B (Classes of Boron Compounds);CHIRAL CHEMICALS;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic Acids;Boronic Acids and Derivatives;organic or inorganic borate;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Monosubstituted Aryl Boronic    Acids;Organometallic Reagents

Mol File:

25487-66-5.mol

image001.gif


3-Carboxyphenylboronic acid Chemical Properties

form 

Crystalline Powder

color 

Off-white

Water Solubility 

2.5 g/100 mL

Appearance:

off-white crystalline powder

Density:

1.406g/cm3

Melting    Point:

243-247ºC

Boiling    Point:

434.512ºC at 760 mmHg

Flash    Point:

216.585ºC

Refractive Index:

1.585

Water Solubility:

2.5 g/100 mL

Storag Condition:

0-6ºC

Vapor  Pressure:

0mmHg at 25°C

BRN 

2967400

CAS DataBase Reference

25487-66-5(CAS    DataBase Reference)


Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

37/39-26-36

WGK Germany 

2

RTECS 

CY8750000

Hazard Note 

Irritant

HazardClass 

IRRITANT

Hs code

2931900090


3-Carboxyphenylboronic acid Usage And Synthesis


Chemical Properties

off-white crystalline powder

Uses

Widely used in Suzuki coupling    chemistry.1,2,3

Uses

suzuki reaction

Intermediate as

451470-34-1 Solabegron

image003_副本.jpg

Synthesis route

image005_副本.jpg

Reference:

Meudt, Andreas; Nerdinger, Sven; Lehnemann,    Bernd Wilhelm Patent: US2009/286995 A1, 2009 ; Location in patent: Page/Page    column 4 

image007_副本.jpg

Reference:

Journal of the American Chemical Society, ,    vol. 134, # 28 p. 11667 - 11673

image009_副本.jpg

Reference:

Journal fuer Praktische Chemie (Leipzig), ,    vol. <2>128, p. 153,169,170

image011_副本.jpg



3-Carboxyphenylboronic acid Preparation Products And Raw materials

Preparation Products

3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC    ACID-->3-(3-PYRIDINYL)BENZOIC    ACID


Upstream information

Methyl 3-bromobenzoate; Ethanol; 3-chlorobenzoic acid; 2-Chloropyrazine; carbon dioxide; 2-Bromo-5-methylbenzoic acid; 5-Bromo-2-picoline; butan-1-ol; 1-bromo-4-methylsulfonylbenzene; 2-bromo-4-chloro-6-nitrophenol;


Downtream information

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 3-Carboxy-5-nitrophenylboronic acid; 3-(2-methoxy-3-nitrophenyl)benzoic acid; 2-Aminobiphenyl-3-carboxylic acid; 4-Acetylbiphenyl-3-carboxylic acid; N-benzyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-pyrazin-2-ylbenzoic acid; 3-aminobenzoic acid; 3-(4-methylsulfonylphenyl)benzoic acid; Methyl 4'-nitro-[1,1'-biphenyl]-3-carboxylate

 

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