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Favorskii Reaction

Lianyungang Klinechem Co.,Ltd | Updated: Dec 06, 2018

Favorskii Reaction

The rearrangement of cyclopropanones, often obtained as intermediates from the base-catalyzed reaction of α-halo ketones, leading to carboxylic acids and derivatives.


Mechanism of the Favorskii Reaction

Esters are obtained if alkoxide bases are used:

A direct conversion from α-halo ketones is possible:

Ring-contraction:


Recent Literature


Halocycloalkenones as Diels-Alder Dienophiles. Applications to Generating Useful Structural Patterns
A. G. Ross, S. D. Townsend, S. J. Danishefsky, J. Org. Chem.201378, 204-210.


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