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Fukuyama Coupling

Lianyungang Klinechem Co.,Ltd | Updated: Dec 06, 2018

Fukuyama Coupling

The palladium-catalyzed coupling of organozinc compounds with thioesters to form ketones. This reaction tolerates a variety of functional groups due to the low reactivity of the organozinc reagents.


Mechanism of the Fukuyama Coupling

Oxidative addition of the thioester is followed by transmetalation from the zinc compound. Reductive elimination leads to the coupled product.

Recent Literature


Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones
H. Tokuyama, S. Yokoshima, T. Yamashita, S.-C. Lin, L. Li, T. Fukuyama, J. Braz. Chem. Soc.19989, 381-387.


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