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Gabriel Synthesis

Lianyungang Klinechem Co.,Ltd | Updated: Dec 07, 2018

Gabriel Synthesis

Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.

Mechanism of the Gabriel Synthesis

Note: Phthalimide is acidic!


Recent Literature

Organic Reactions in Ionic liquids: N-Alkylation of Phthalimide and Several Nitrogen Heterocycles
Z.-G. Le, Z.-C. Chen, Y. Hu, Q.-G. Zheng, Synthesis2004, 208-212.

A convenient Two-Step Procedure for the Synthesis of Substituted Allylic Amines from Allylic Alcohols
S. E. Sen, S. L. Roach, Synthesis1995, 756-758.

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