Lianyungang Klinechem Co.,Ltd
call us on: +86-518-88103268
English中文
Knowledge
Home > Knowledge > Content

Hofmann's Rule

Lianyungang Klinechem Co.,Ltd | Updated: Dec 07, 2018

Hofmann's Rule

Hofmann's Rule implies that steric effects have the greatest influence on the outcome of the Hofmann or similar eliminations. The loss of the β-hydrogen occurs preferably from the most unhindered (least substituted) position [-CH3 > -CH2-R > -CH(R2)]. The product alkene with fewer substitutents will predominate.

Ester Pyrolysis also obeys this preference, and the Hofmann Rule is generally followed whenever a reaction passes through a cyclic transition state.

Hofmann's Rule is valid for all intramolecular eliminations and for the Hofmann Elimination. Most bimolecular eliminations will follow Saytzeff's Rule.


Contact Us
Address: Jingqi Road, Weiwu Road, Coastal Industrial Park, Guanyun County, Lianyungang City, Jiangsu Province
Tel:+86-518-88103268
Fax:+86-518-88103267
E-mail:sales@klinechem.com

© Lianyungang Klinechem Co.,Ltd