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Iwanow Reaction (Ivanov Reaction)

Lianyungang Klinechem Co.,Ltd | Updated: Dec 11, 2018

Iwanow Reaction (Ivanov Reaction)

Ivanov Reagents are carboxylate enolates (enediolates, or carboxylic acid dianions) derived from phenyl acetic acid or substituted analogs, and react with aldehydes to give β-hydroxy acids, similar to the Aldol Addition.

The stereoselectivity can be explained with the Zimmerman-Traxler Model, which predicts a six-membered cyclic transition state leading to excellent stereoselectivity for anti-substituted products.

Mechanism of the Iwanow Reaction

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