Lianyungang Klinechem Co.,Ltd
call us on: +86-518-88103268
Home > Knowledge > Content

Rubottom Oxidation

Lianyungang Klinechem Co.,Ltd | Updated: Dec 17, 2018

Rubottom Oxidation

The synthesis of α-hydroxy ketones is achieved by reaction of silyl enol ethers with mCPBA, with subsequent rearrangement. Aqueous work up or reaction with TBAF (fluoride ions) gives the desired product after desilylation

Mechanism of the Rubottom Oxidation

The enol ether double bond is epoxidized by the peracid. Relief of the epoxide ring strain drives the rearrangement with migration of the silyl group to give the silylated α-hydroxy ketone product.

Contact Us
Address: Jingqi Road, Weiwu Road, Coastal Industrial Park, Guanyun County, Lianyungang City, Jiangsu Province

© Lianyungang Klinechem Co.,Ltd