Lianyungang Klinechem Co.,Ltd
call us on: +86-518-88103268
Home > Knowledge > Content

Willgerodt-Kindler Reaction

Lianyungang Klinechem Co.,Ltd | Updated: Dec 11, 2018

Willgerodt-Kindler Reaction

The Willgerodt Reaction allows the synthesis of amides from aryl ketones under the influence of a secondary amine and a thiating agent. The mechanism involves the formation of an enamine which undergoes thiation, and the carbonyl group migrates to the end of the chain via a cascade of thio-substituted iminium-aziridinium rearrangements.

The Kindler Modification is more convenient:

Hydrolysis of the thioamide provides the amide.

Mechanism of the Willgerodt-Kindler Reaction


Recent Literature

Efficient Synthesis of Thiobenzanilides by Willgerodt-Kindler Reaction with Base Catalysts
K. Okamoto, T. Yamamoto, T. Kanbara, Synlett2007, 2687-2690.

Preparation of Thioamide Building Blocks via Microwave-Promoted Three-Component Kindler Reactions
O. I. Zubruyev, N. Stiasni, C. O. Kappe, J. Comb. Chem., 20035, 145-148.

Contact Us
Address: Jingqi Road, Weiwu Road, Coastal Industrial Park, Guanyun County, Lianyungang City, Jiangsu Province

© Lianyungang Klinechem Co.,Ltd