Boc-Aib-OH Basic information Boc-Aib-OH Chemical Properties Safety Information Boc-Aib-OH Usage And Synthesis Boc-Aib-OH Preparation Products And Raw materials Upstream information 2-aminoisobutyric acid; tert-butyl fluoroformate; 1,4-Dioxane; D-tryptophan; iodomethane;...
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Product Name: | Boc-Aib-OH |
Synonyms: | RARECHEM EM WB 0052;N-BOC-2-AMINOISOBUTYRIC ACID;N-ALPHA-T-BUTOXYCARBONYL-ALPHA-AMINOISOBUTYRIC ACID;2-Methyl-2-(tert-butoxycarbonylamino)propionic acid;N-(tert-Butoxycarbonyl)-2-methylalanine;N-(tert-Butoxycarbonyl)-2-methyl-L-alanine;BOC-alpha-Methylalanine,98%;N-ALPHA-T-B |
CAS: | 30992-29-1 |
MF: | C9H17NO4 |
MW: | 203.24 |
EINECS: | 250-421-0 |
Product Categories: | Amino Acids |
Mol File: | 30992-29-1.mol |
Boc-Aib-OH Chemical Properties
form | Crystalline Powder |
color | White |
Appearance: | Liquid. |
Density: | 1.103 g/cm3 |
Melting Point: | 117-121ºC |
Boiling Point: | 327.6ºC at 760 mmHg |
Flash Point: | 151.9ºC |
Storage Condition: | 0-6ºC |
BRN | 1953772 |
InChIKey | VLHQXRIIQSTJCQ-LURJTMIESA-N |
CAS DataBase Reference | 30992-29-1(CAS DataBase Reference) |
Safety Information
Safety Statements | 24/25 |
WGK Germany | 3 |
HazardClass | IRRITANT |
HS Code | 29241990 |
Safety Statements | 24/25 |
WGK Germany | 3 |
HazardClass | IRRITANT |
HS Code | 29241990 |
Boc-Aib-OH Usage And Synthesis
Chemical Properties | white crystalline powder |
Description | Boc-a-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids. |
Uses | Boc-pseudo-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives(isocoumarin) as well as arylbenzeneacetic acids. |
Intermediate as | 159752-10-0 MK677(mesylate salt) |
Synthesis route | Reference:Kondo;Kimura;Sato;Horimoto Bulletin of the Chemical Society of Japan, 1987 ,vol.60,#4 p.1391 - 1397 Smithkline Beckman Corporation Patent: US4876243 A1, 1989 ; US 4876243 A US5332734 A1 Tetrahedron, , vol. 38, # 14 p. 2165 - 2182 Camphausen, Kevin;Sproull, Mary; Tantama, Steve; Venditto, Vincent; Sankineni, Sandeep; Scott,Tamalee; Brechbiel, Martin W. Bioorganic and Medicinal Chemistry, 2004 , vol. 12,#19 p.5133 - 5140 Frerot, Eric;Coste,Jacques; Pantaloni, Antoine; Dufour, Marie-Noelle; Jouin, Patrick Tetrahedron, 1991 , vol. 47, # 2 p. 259 - 270 Principia Biopharma Inc.; Goldstein, David Michael Patent:US8673925 B1,2014;Location in patent: Page/Page column 253 Reference:Synthesis, , # 6 p. 607 - 626 Reference:Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182 |
Boc-Aib-OH Preparation Products And Raw materials
Upstream information
2-aminoisobutyric acid; tert-butyl fluoroformate; 1,4-Dioxane; D-tryptophan; iodomethane; 2-ISOCYANATO-2-METHYLPROPANOIC ACID METHYL ESTER; tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate; 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; tert-butyl N-diazocarbamate; Boc-Aib-OEt;
Downtream information
2-aminoisobutyric acid; D-Tryptophan, N-[N-[(1,1-dimethylethoxy)carbonyl]-2-methylalanyl]-; 2-Amino-2-methylpropanamide hydrochloride; tert-butyl N-(1-amino-2-methyl-1-oxopropan-2-yl)carbamate; tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate; N-BOC-N,2-Dimethylalanine; 5,5-Dimethylhydantoin; tert-butyl N-(1-hydroxy-2-methylpropan-2-yl)carbamate; 2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;
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